感染、炎症的神经免疫调控.pptx

感染、炎症的神经免疫调控.pptx课件模板文档，格式 pptx，大小 1.51 MB，共约28页。以下是概述： 感染、炎症的神经免疫调控体液、细胞和神经对感染、炎症的调控迷走神经的支配示意图From:http://medical-dictionary.thefreedictionary.com/vagus+nerveBorovikova&Tracey,2000迷走神经对感染、炎症的调控LPSorCLPLPSorCLPLPSorCLPAndersson&Tracey2011Wang&Tracey,2003,2004乙酰胆碱受体调控影响感染死亡率LPSorCLPLPSorCLP7nAChRko7nAChRagonist7nAChRkoLPSorCLPheteromerichomomericmuscle-typeNeuronaltype7烟碱型乙酰胆碱受体(7nicotinicacetylcholinereceptor)Wang,etal.Nature2003巨噬细胞表达7烟碱型乙酰胆碱受体Matthay,etal.NatureMedicine2004Su,etal.JI2005激活巨噬细胞7nAChR减轻炎症反应Rosa-Ballina&Tracey,Science,2011脾脏CHAT表达T细胞调控感染、炎症LPSorCLPCellsSpeciesModelsInterventionsRefsMacrophagesHumanMouseSepsis;CLP;Acid-inducedALI;Pneumoniaα7nAChRagonists,VNS,Geneticdepletion(6,10,33,35)MonocytesHumanInvitrocellcultureα7nAChRagonists(52,53)NeutrophilsMouseSepsis;LPS-inducedALI;Acid-inducedALIα7nAChRagonists,VNS,Geneticdepletion(33,35,54)Mononuclearcells(MNCs)RatsPOCD;Metabolicsyndromeα7nAChRagonists:PHA,β2adrenergicagonist(55)Dendriticcells(DCs)MouseImmaturedendriticcells(imDCs);HBVimmunotherapyNicotine(56)Tlymphocytes;BlymphocytesMouseSepsisInfectionα7nAChRgeneticdepletion;bonemarrowtransplantation(9,57-60)EpithelialcellsRats,human,mouseInvitrocellculture,Lunginjurymodelsα7nAChRagonist:nicotineGeneticdepletionofα7nAChR(33,61-64)EndothelialcellsHumanmouseInvitrocellculture,Sepsismodelα7nAChRagonists:nicotine,CAP55(65-67)HematopoieticstemcellsMouseSepsisα7nAChRCre,Rosa26-Flox,YFPlabeling;Bonemarrowtransplantation(68)MesenchymalstemcellsHumanCellcultureα7nAChRagonists:nicotine,(69,70)EndothelialprogenitorcellsHumanMouseCellculture,Ischemiamodelα7nAChRagonists:nicotine,(71,72)FibroblastHumanMouseArthritispatientsandmodelsImmunofluorescence;depletionofα7nAChR(73,74)7nAChR影响炎症、免疫、干细胞unpublishedPathwaysSpeciesModelsInterventionsOutcomeRefsTLRsMyD88HumanRatsCellculture:Epithelialcells;macrophagesormonocytesTLRsagonists;α7nAChRagonists:NicotineorGTS-21pretre...